Instructor: V.J. Davidson

Office: Room 2333, Thornbrough Building

School of Engineering

Ext.: 54367

Email: vdavidso@uoguelph.ca

Office hours: Wednesday 2 - 4 pm

Lectures: Tues./Thurs. 8:30 am - 9:50 am, MacKinnon 228

Seminar: Thurs. 10:00 - 10:50 am, MacKinnon 231

Teaching Assistant: K. Conrad Email: kconrad@uoguelph.ca

Course Description:

Bioengineering is a broad discipline that integrates engineering principles with biological sciences. Applications include biochemical and food engineering, biomedical engineering and bioresource engineering. Systems identification and analysis are common to all of these areas and form the foundation for engineering design.

This course uses techniques and tools developed in ENGG*2400 to analyse mass and energy components of biological systems. We will focus on systems containing biological catalysts (e.g. cells, enzymes) and/or other reacting species. A range of bio-system examples will be used: biomedical, food and bio-processing.

Prerequisite: MATH*2270, MICRO*1020

Co-requisite: CHEM*2580, STAT*2120

Objectives:

Students who successfully complete this course will be able to:

1. Identify and analyse mass and energy transformations in biological systems

2. Develop mathematical models for bio-systems and analyse their dynamic behaviour.

3. Integrate fundamental principles of microbiology and biochemistry with quantitative analysis to solve engineering problems.

4. Use advanced mathematical, statistical and computer tools for systems analysis.

Topics:

• Biological systems analysis - comparisons to electrical, hydraulic, thermal and mechanical systems

• Cell physiology and growth requirements (mammalian, fungal and bacterial systems)
• Mass balances- conservation of mass- process flow diagrams- mass balances without reaction- mass balances with reaction- total mass vs. composition- steady state and dynamic systems

• Energy balances-conservation of energy- enthalpy, heats of reaction, energy of phase changes

• Reaction kinetics- kinetics of cell growth and product formation- enzyme kinetics- first-order kinetics- temperature effects

• Special topics - pharmacokinetics (compartmental analysis)- tissue engineering-heterogeneous reactions (immobilized enzymes)
  

Recommended Textbook:

Bioprocess Engineering Basic Concepts (second edition) M. L Shuler and F. Kargi. PrenticeHall PTR, New Jersey 2002

Additional references (2 hour reserve)

Bioprocess Engineering Principles P. M. Doran Academic Press, Toronto 1995 (TP 248.3.D67)

Bioprocess Engineering Basic Concepts (first edition) M. L Shuler and F. Kargi. PrenticeHall PTR, New Jersey 1992 (TP248.3 .S58)

Assessment:

Term tests (2) 40% (Thursday, February 14^th and Thursday, March 21st)

Technical report 20% (Due: Tuesday, April 2nd)

Final examination 40 % (16-Apr-02 2:30pm - 4:30pm)

TOTAL 100 %

Problem assignments will be set on a weekly basis and it is recommended that students work on the problems during the seminar hour (Thursday mornings). Solutions will not be posted. The instructor and teaching assistant will provide help during seminar and office hours.